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 RESPIRATION

KREB'S CYCLE

Enzymes located in the inner matrix of mitochondria (in eukaryotes)

Note: Number of mitochondria per cell = activity of the cell. On average 1000 per cell (between 20 and 10 000)

Step 1: Synthesising ACETYL COENZYME A:

Step 2: Oxidising Acetyl CoA:

The Kreb's Cycle was discovered by using inhibitors (eg malonate) and isolating enzymes from tissues rich in mitochondria (eg bird flight muscle).

Total ATP from 1 molecule of glucose in AEROBIC CONDITIONS

   

ATP
Glycolysis used in phosphorylation

- 2
  gained by oxidation

+ 8
Kreb's Cycle gained by oxidation

+ 30
TOTAL  

+ 36

© Paul Billiet 2008