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Powerpoint Presentation: Enzyme Inhibition

Biochemistry: Enzyme Index

Enzymes
Enzyme Mechanisms
Factors Affecting Enzymes: Substrate concentration
Factors Affecting Enzymes: pH
Factors Affecting Enzymes: Temperature
Enzymes and Homeostasis
Enzymes and Biotechnology
Catalase

Topic Chapters Index

 

Applications of inhibitors

Negative feedback - see end point or end product inhibition

Poisons snake bite, plant alkaloids and nerve gases.

Medicine antibiotics, sulphonamides, sedatives and stimulants

 

 

BIOCHEMISTRY

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The effect of enzyme inhibition

Irreversible inhibitors: These combine with the functional groups of the amino acids in the active site, irreversibly.

Examples: nerve gases and pesticides, containing organophosphorus, combine with serine residues in the enzyme acetylcholine esterase.

 

Reversible inhibitors: These can be washed out of the solution of enzyme by dialysis. There are two categories.

Competitive: These compete with the substrate molecules for the active site.

The inhibitors action is proportional to its concentration.

 

Competitive Inhibition

 

Usually this type of inhibitor resembles the substrate's structure closely

 

Example competitive inhibition

 

If more substrate is added, the effect of the inhibitor is reduced.

 

Non-competitive: These are not influenced by the concentration of the substrate. It inhibits by binding irreversibly to the enzyme but not at the active site

Examples
Cyanide combines with the Iron in the enzymes cytochrome oxidase.
Heavy metals, Ag or Hg, combine with -SH groups.
These can be removed by using a chelating agent such as EDTA.

 

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