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Powerpoint Presentation: Sex Linkage

 

Genetics Index

Chromosomes
Meiosis
Meiosis: Crossing over
Mitosis and Meiosis
Introduction to Mendelian Genetics
Test Cross
Codominance
Multiple Alleles
Pedigree Charts
Twin Studies
The dihybrid cross
Dihybrid Cross : Test Cross
Autosomal Linkage
The Genetic Diagram for Linked Genes
Calculating the cross over value using a test cross
Sex determination and sex linkage
Sex linkage
Genetic diagram for sex linked genes
The Retina and Daltonism
Genetic Modification
Cloning Animals
Cloning Plants

Topic Chapters Index

 

GENETICS

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Blood Clotting and Haemophilia

A simplified scheme of the important steps

 

Blood Clotting and Haemophilia

 

A more complete picture showing the antihaemophilic factors

The blood clotting reaction is an enzyme cascade involving Factors XII, XI, IX, X and II. Each of these enzymes are proteases that cut (or cleave) the next protein in line thus activating it. Other factors including proteins like Factor VIII are essential as coenzymes.

 

Heamophilia

About 85% of haemophiliacs suffer from classic haemophilia (1 male in 10000). they cannot produce factor VIII. The rest show Christmas disease where they cannot make factor IX.

Haemophiliacs do clot their blood slowly because there is an alternative pathway via thromboplastin.

The genes for both forms of haemophilia are sex linked.

 

both forms of haemophilia

 

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